Definition
What AST/ALT Ratio measures
The AST/ALT (De Ritis) ratio divides the two common transaminases from the same draw. It is calculated, not a new assay.
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AST/ALT Ratio
The De Ritis proportion of the two transaminases
Illustrative sample band · Synthetic
0.9ratio
0.3Sample target 0.6–1.1 ratio2.1
Why it matters
How clinicians usually read it
The proportion sometimes helps a clinician think about alcohol-related injury versus a more ALT-dominant pattern. The raw enzymes still matter more than the ratio.
When it reads low
A lower value can mean
A lower ratio usually means ALT is the louder enzyme, a common pattern in metabolic liver fat. It is context, not a diagnosis.
When it reads high
A higher value can mean
A higher ratio means AST is relatively louder. Alcohol, muscle injury, and cirrhosis-pattern reads all live in this neighborhood and need clinical review.
Questions for a clinician
Bring the number into a real conversation
01
Should I care about this ratio or just the raw ALT and AST?
02
Could muscle injury be lifting AST and the ratio?
03
Does this change any follow-up imaging or interval?
Educational boundary
Educational information only. Displayed ranges are illustrative sample bands, not a diagnosis, treatment plan, or substitute for the contracted laboratory report and a qualified clinician.
See it as a sample result
The sample dashboard shows an illustrative reading, target band, and trend for AST/ALT Ratio.